![]() However, trains of intense photic stimulation was efficacious in inducing neuroplastic changes leading to photoparoxysmal activity in normal young adult Sprague-Dawley rats. Photic stimulation in the genetic epileptic models does not provoke a photoparoxysmal response, as has been found in some absence epilepsy patients. Flash VEPs made during spike-wave discharges (SWDs) in the genetic animal absence models have revealed that their sensory system is largely intact interestingly the state of the brain during SWDs mimics that of slow-wave sleep. These ADs are generated in cortico-geniculate-cortical pathways and have been used as a model for the evaluation of putative anti-absence drugs, while properties of flash-evoked VEPs were also used to predict toxic effects of new compounds, including putative anticonvulsant drugs. Albino rats have a higher amplitude of the late complex of the flash-induced visual evoked potential (VEPs) and afterdischarges (AD), the latter in particular during low states of arousal and vigilance than hooded and pigmented rats.
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